![]() ![]() ![]() Those bacteria colonize the newborn’s gut and help build immunity. Babies born via vaginal delivery are exposed to certain maternal bacteria as they pass through the birth canal. “Now, our findings suggest that delivery via C-section and early treatment with antibiotics also play an important role in this serious allergic disease.”Īlthough more research is needed to understand the precise mechanism by which C-section birth and antibiotics lead to EoE, the researchers suspect these two factors precipitate serious shifts in the composition of a baby’s developing gut. “It is becoming increasingly clear that the early development and composition of our gut bacteria can influence immunity for life,” says study lead investigator Corinne Keet, M.D., Ph.D., a pediatric allergist at the Johns Hopkins Children’s Center. Because EoE’s cardinal symptoms - heartburn, swallowing difficulties and persistent burping - mimic garden-variety gastritis, biopsy of the esophagus remains the only definitive way to distinguish between the two disorders. ![]() ![]() The condition is marked by irritation, inflammation and constriction of the esophagus and by proliferation of eosinophils, or immune cells that multiply during allergic reactions. While still relatively rare, EoE appears to be on the rise in both children and adults, research shows. The findings, published online May 2 in the Journal of Allergy and Clinical Immunology: In Practice, reveal that early antibiotic treatment and C-section delivery may somehow precipitate disease development by altering a child’s microbiota - the trillions of bacteria and other organisms residing in human intestines that regulate digestive health and immunity.Įosinophilic esophagitis, or EoE, is an emerging allergic disease, the causes of which remain unclear. The findings underscore the importance of judicious use of antibiotics, especially during infancy, as well as the importance of finding alternative ways to expose C-section delivered babies to beneficial maternal bacteria.Ĭhildren delivered by cesarean section and those given antibiotics during early infancy appear more prone to developing allergic inflammation of the esophagus - the muscular tube that connects the mouth to the stomach - according to results of a study by investigators from the Johns Hopkins Children’s Center and Harvard Medical School.Further studies are needed to establish the precise mechanism by which C-section birth and antibiotics precipitate the disease, but investigators believe that antibiotic use in infancy appears to impede the growth of certain beneficial gut bacteria responsible for digestive health and normal immunity, and that C-section delivery prevents a baby’s exposure to important maternal bacteria in the vaginal canal that go on to colonize a baby’s gut and help build immunity.Babies born via C-section, and those treated with antibiotics early in life appear more prone to allergic inflammation of the esophagus, a condition known as eosinophilic esophagitis (EoE).Short Labor: Characteristics and Outcome. Short Interpregnancy Intervals and Adverse Maternal Outcomes in High-Resource Settings: An Updated Systematic Review. Hutcheon J, Nelson H, Stidd R, Moskosky S, Ahrens K. Emergency Medicine Clinics of North America. Epidemiology of Unplanned Out-Of-Hospital Births Attended by Paramedics. McLelland G, McKenna L, Morgans A, Smith K. Clinical Significance of Precipitous Labor. NB: hypertensive disorders of pregnancy are chronic hypertension, preeclampsia- eclampsia and gestational hypertension 5 See also multivariate analysis in a 2015 study looked at nullips and multips mothers as separate groups, identifying the following independent risk factors 1.Pregnant mothers are more likely to experience precipitous labor if they are multiparous 1. EpidemiologyĪmerican data shows that precipitous labor accounts for up to 3% of all births, although a large Japanese study of over 11,000 singleton births from 2015, found ~14% were precipitous in nature 1,2. Contradictory and somewhat limited data demonstrates a higher risk of pregnancy-related complications 1,6. Precipitous labor, also known as precipitous birth, is labor that happens too quickly, and is formally defined as fetal expulsion three hours or less after the start of regular uterine contractions. ![]()
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